Lethal Decisions
The Unnecessary Deaths of Women and Children from HIV/AIDS

How proven treatments for HIV/AIDS were found, then withheld for decades from people in poor countries.

Arthur J. Ammann, MD
Foreword by Michael Gottlieb, MD
Published by Vanderbilt University Press, January 2017

This first-person account by one of the pioneers of HIV/AIDS research chronicles the interaction among the pediatric HIV/AIDS community, regulatory bodies, governments, and activists over more than three decades. After the discovery of AIDS in a handful of infants in 1981, the next fifteen years showed remarkable scientific progress in prevention and treatment, although blood banks, drug companies, and bureaucrats were often slow to act. 1996 was a watershed year when scientific and clinical HIV experts called for treating all HIV-infected individuals with potent triple combinations of antiretroviral drugs that had been proven effective. Aggressive implementation of prevention and treatment in the United States led to marked declines in the number of HIV-related deaths, fewer new infections and hospital visits, and fewer than one hundred infants born infected each year.

Inexplicably, the World Health Organization recommended withholding treatment for the majority of HIV-infected individuals in poor countries, and clinical researchers embarked on studies to evaluate inferior treatment approaches even while the pandemic continued to claim the lives of millions of women and children. Why did it take an additional twenty years for international health organizations to recommend the treatment and prevention measures that had had such a profound impact on the pandemic in wealthy countries? The surprising answers are likely to be debated by medical historians and ethicists.

At last, in 2015, came a universal call for treating all HIV-infected individuals with triple-combination antiretroviral drugs. But this can only be accomplished if the mistakes of the past are rectified. The book ends with recommendations on how the pediatric HIV/AIDS epidemic can finally be brought to an end.

Lethal Decisions - The Unnecessary Deaths of Women and Children from HIV/AIDS

Recent Reviews

In the aftermath of cataclysmic events a witness often comes forth to tell us how it came about and point to pivotal opportunities that would have minimized its impact. Dr. Arthur Ammann, the doctor who identified the first cases of AIDS in children and the transmission of HIV by blood transfusion, is such a witness. Lethal Decisions is his highly personal account of an ongoing disaster, the global HIV epidemic in children and mothers, and the world’s fatally flawed response.”
Michael Gottlieb, MD. Dr. Gottlieb discovered the Acquired Immunodeficiency Syndrome (AIDS) in 1981.
Arthur Ammann, a veteran in the war against AIDS, has meticulously chronicled the history of pediatric HIV infection and examined the causes for the unnecessary delays in implementing best practices to block mother-to-child transmission of HIV in the developing world. This retrospective re- evaluation provides valuable lessons as we prospectively confront public health challenges, now and in the future.”
David D. Ho, MD. Director, Aaron Diamond AIDS Research Center; Time magazine Man of the Year, 1996
Mobilizing the resources to understand and react to save the lives of millions of women and their children is the gripping story told in Lethal Decisions by Arthur Ammann, the pioneer in this epic quest. This is a vital contribution to our understanding of what did and didn’t work in confronting AIDS in the hope that we can avoid our mistakes in future epidemic outbreaks.”
Paul Volberding, MD, Director, AIDS Research Institute, University of California San Francisco. In 1987 Volberding co-led the first study of successful treatment of HIV-infected individuals with an antiretroviral drug.
In Lethal Decisions, Arthur Ammann traces the history of the pediatric HIV/AIDS epidemic from the early discoveries and extraordinary successes through the dark period of inexcusable delays in prevention and treatment. He does not hesitate to point out that the large and powerful health organizations must be held accountable for their recommendations to withhold effective prevention and treatment measures from millions until HIV progressed to advanced stages of infection. ”
Anne Firth Murray teaches International Women’s Health and Human Rights at Stanford University. She is the Founding President of the Global Fund for Women and the author of From Outrage to Courage: The Unjust and Unhealthy Situation of Women in Poorer Countries and What They Are Doing about It.

About the Author

Arthur J. Ammann MD is Founder of Global Strategies and Clinical Professor of Pediatrics at the University of California. His pivotal research studies on vaccines resulted in the first FDA approval of a pneumococcal vaccine for infants, children and the elderly. In 1982 Dr. Ammann described two of the three ways that HIV is transmitted including from mother to infant and the first blood transfusion associated AIDS patient. He is the recipient of more than 50 national and international awards, has authored over 300 scientific papers, is the author of three books, and has taught in numerous European, South America, Asian, Central American, and African countries.

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Arthur Ammann - Author - Lethal Decisions